重症急性胰腺炎大鼠并发肠黏膜屏障功能障碍OACSTPCD
Severe acute pancreatitis rats complicated with intestinal barrier fuctional disturbance
目的 探讨重症急性胰腺炎(SAP)大鼠肠黏膜屏障功能的状况.方法 48只SD大鼠,随机分两组:假手术组(A组,n=24)、SAP模型组(B组,n=24).用3％牛磺胆酸钠制备SAP大鼠模型.麻醉苏醒,即开始灌胃,6h/次,A、B组用灌胃器按1 mL/100g/次生理盐水灌胃.制模后各组在6、12、24h3个时间点取材；开腹后观察腹水量及其颜色,观察胃肠道大体情况；取血用酶联免疫吸附双抗夹心法检测血清二胺氧化酶(DAO)及D-乳酸浓度；取胰腺及回肠…查看全部>>
Objective To observe the effects of rats severe acute pancreatitis complicated with intestinal barrier functional disturbance (IBFD). Methods Forty-eight healthy SD rats were randomly divided into two groups; sham operation group (group A, n =24) , SAP model group (group B, n = 24). The rats in group B with severe acute pancreatitis were induced by retrograde injection of 3% sodium taurocholate into eholangiopancreatic tube. The rats in group A were only fli…查看全部>>
蔡治方;兑丹华;王俊
遵义医学院第一临床学院,贵州遵义563003遵义医学院第一临床学院,贵州遵义563003遵义医学院第一临床学院,贵州遵义563003
医药卫生
胰腺炎肠黏膜屏障功能D-乳酸二胺氧化酶
pancreatitis intestinal barrier functional disturbance D-lactate diamine oxidase
《山东医药》 2012 (20)
22-24,封3,4
贵州省科技厅中医药现代化攻关项目(黔科合中药专字[2003]13号).
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