摘要
Abstract
Objective: To evaluate the efficacy and safety of Biyanning Granule on moderate to severe persistent allergic rhinitis. Methods: To compare efficacy, quality of life, safety of Biyanning and Cetirizine hydrochloride tablet on lop of Budesonide nasal spray in 177 patients. Group A was treated with Budesonide nasal spray, group B with Budesonide plus Biyanning Granule, group C with Budesonide plus Cetirizine hydrochloride tablet Results: After one week,the effective rates of group A, B and C was 47% ,67% and 74% ,and there was significant difference between group A and B or A and C(P<0.05) , but not significant between group B and C(P >0. 05). After two weeks, the effective rates of group A, B and C was 60% , 79% and 82% .there was significant difference between group A and B or A and C (P < 0. 05), but not significant between group B and C (P > 0. 05 ). There was significant improvement of quality of life after treatment for all groups (P < 0. 05). Quality of life of Group A was significantly better than that of group B or C, but not significant between group B and C. Without severe adverse reaction, the AE occurrence rates were 13. 3 % , 15. 3 % and 22. 4 % . Conclusion: Biyanning Granule has corrective efficacy for moderate to severe persistent allergic rhinitis. The combined effect with Budesonide nasal spray is as good as Cetirizine Hydrochloride with less adverse drug reactions.关键词
鼻炎宁颗粒/布地奈德鼻喷剂/盐酸西替利嗪片/变应性鼻炎Key words
Biyanning Granule/ Budesonide Nasal Spray/ Cetirizine Hydrochloride Tablets/ Allergic rhinitis
