色谱2012，Vol.30Issue(3)：273-279,7.DOI:10.3724/SP.J.1123.2011.11022
气相色谱-质谱法同时测定化妆品中19种邻苯二甲酸酯
Simultaneous determination of 19 phthalate esters in cosmetics using gas chromatography-mass spectrometry
摘要
Abstract
A method was developed for the simultaneous determination of 19 phthalate esters ( PAEs) at trace level in cosmetics by solid phase extraction (SPE) purification and gas chromatography-mass spectrometry (GC-MS) detection. The PAEs were extracted from cosmetic samples by dichloromethane with ultrasonic-assisted technique, purified by an SPE column packed with silica gel and neutral alumina (2:3, m/m) with the elution of 20 mL of mixed solvent of ethyl acetate-hexane (8= 2, v/v). Qualitative and quantitative analysis were carried out by GC-MS in full scan and selected ion monitoring modes. The retention time of quantitative ions and the abundance ratio of characteristic ions were applied to rapidly and accurately identify each analyte so as to prevent the occurring of possible mistakes from complex matrix intervention. Under optimized conditions, the average recoveries for a shampoo sample spiked with the standards at 0.1, 0. 5, 2.0μg/g were in the range of 72. 2% and 110. 9%, and the relative standard deviations (RSDs) for the 19 PAEs were less than 10. 3% (n =6) at the spiked level of 0. 1μg/g. The limits of detection (LODs, as 3 times of standard deviation) were between 0. 006 5 μg/g (for diisopentyl phthalate) and 0. 062μg/g (for diisobutyl phthalate). The method was successfully applied to the determination of the PAEs in 6 types of cosmetics. It is expected to promote the determination of the PAEs in other cosmetics with different matrices.关键词
气相色谱-质谱/邻苯二甲酸酯/化妆品Key words
gas chromatography-mass spectrometry (GC-MS)/ phthalate esters (PAEs)/ cosmetic分类
化学化工引用本文复制引用
梁婧,庄婉娥,魏丹琦,欧延,弓振斌..气相色谱-质谱法同时测定化妆品中19种邻苯二甲酸酯[J].色谱,2012,30(3):273-279,7.基金项目
福建省食品药品监督管理局和福建远东技术服务有限公司委托项目. （）
