陕西师范大学学报：自然科学版2012，Vol.40Issue(2)：71-75,5.
二氢卟吩e6在小鼠S180肉瘤中的代谢分布
Metabolism and distribution of chlorin e6 in S180 tumor-bearing mice
摘要
Abstract
To study the absorption, clearance and other pharmacokinetic characteristics of Chlorine6, and to provide some scientific basis for SDT disposed at different position of tumor, the distribution of chlorin e6 （Ce6） in S180 tumor-bearing mouse was observed. After intravenous injection of the Ce6 in the mice at different time, the fluorescence intensity was determined to estimate its concentration and distribution in the different tissues. The results indicated that the Ce6 in each tissue increased to a peak value within 0.5 hours, and the Ce6 in the tumor had the highest concentration within 4 hours. The Ce6 has the advantages in tumor selectivity, longer retention, and it can quickly metabolize from normal tissues, and has a good prospect for clinical application. According to different metabolic rate in each tissue, tumors at different site should be treated at appropriate time respectively. Based on these results, some information of Ce6 can be applied in clinical diagnosis.关键词
二氢卟吩e6/S180肉瘤/荧光分光光度法Key words
chlorin e6/S180 tumor-bearing/spectrofluorophotometry分类
生物科学引用本文复制引用
王璐,陈雁,朱思佳,史海涛,王攀,刘全宏..二氢卟吩e6在小鼠S180肉瘤中的代谢分布[J].陕西师范大学学报：自然科学版,2012,40(2):71-75,5.基金项目
国家自然科学基金资助项目 （）
教育部高等学校博士学科点专项科研基金 （）
陕西师范大学勤助科研创新基金项目（QZYB10014）. （）
