陕西医学杂志2012，Vol.41Issue(6)：655-657,3.
运动对大鼠学习记忆功能和海马CA3区HDAC2表达的影响
The effect by exercise on function of Rat's learning and memory as well as HDAC2 expression in hippocampal CA3 region
刘远新1
作者信息
- 1. 西安体育学院运动医学教研室,西安710068
- 折叠
摘要
Abstract
Objective:To reveal the effect on function of rat's learning and memory as well as HDAC2 expression in hippocampal CA3 region by moderate and incremental treadmill exercise. Methods: Male rats in developing period were randomly divided into control and exercise groups. Rats in latter group underwent incremental moderate exercise on treadmill for 8 weeks. The Morris water maze was then immediately employed to verify learning and memory of rats in both groups before being executed. Materials drawn from the hippocampus CA3 region were then processed by immunohistochemistry to assess CA3 HDAC2 protein expression. Results:It is found in navigation experiment that the escape latency of rats in exercise group was significantly reduced compared with that of the control group (P <0. 01). Both the diration of target quadrant movement and the platform-crossing number of rats in exercise group increased significantly compared that of control group with difference being statistically significant (P <0. 01). Meanwhile, HDAC2 protein expression in exercise group was significantly lower than that of control group (P <0. 05). Conclusion: The exercise in moderate-intensity can cause the diminished hippocampal CA3 HDAC2 expression in rat's brain. It indicates that the improvement of learning and memory can be realized through appropriate long-term exercise which make possible inhibition of HDAC2 expression.关键词
大鼠/运动/海马CA3区/组蛋白去乙酰基酶2Key words
Rats/Exercise/CA3 region, hippocampal/Histone deacetylase 2分类
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刘远新..运动对大鼠学习记忆功能和海马CA3区HDAC2表达的影响[J].陕西医学杂志,2012,41(6):655-657,3.
