实用妇产科杂志2012，Vol.28Issue(3)：211-214,4.
激活素A、Bax和XIAP在特发性胎儿生长受限患者的表达及意义
The Expression and Significance of Activin A, Bax and XIAP in Idiopathic Fetal Growth Restriction
摘要
Abstract
Objective:To investigate the expression and significance of Activin A in maternal and cord serum idiopathic fetal growth restriction (IFGR), B-cell lymphoma associated x protein (Bax), and X-linked inhibitor of apoptosis protein (XIAP) in placenta of idiopathic fetal growth restriction (IFGR). Methods:From July 2010 to May 2011, 30 pregnant women with IFGR underwent cesarean section in our hospital were selected as experimental group, and 30 normal term pregnant women underwent cesarean section due to social factors were matched as control group. Activin A in maternal and umbilical cord serum were analyzed by enzyme-linked immunosorbent assay (ELISA), while Bax and XIAP in placenta were detected by immunohis-tochemical method. Results:The level of Activin A both in maternal and cord serum of the experimental group (102. 659 ±16.467, 57.752 ±13.498) ng/ml ,were significantly higher than those in control group (75. 927 ±10. 519,29. 870 ±5. 992) ng/ml(P<0.05). The expression of Bax in placental syncytiotropho-blast in experimental group (146. 513 ± 10. 611) was significantly increased as compared to the control group (113. 672 ±9. 631) (P <0. 05). The expression of XIAP in placental syncytiotrophoblast in experimental group (114. 562 ±5.167) was significantly decreased as compared to the control group (144. 430 ± 7. 311) (P <0. 05). The level of Activin A in maternal and cord serum was positively correlated with the expression of Bax in placenta in experimental group (p<0. 05), whilst it showed negative correlation with the expression of XIAP in placenta in experimental group (P<0. 05). Moreover, the expression of XIAP in syn-cytiotrophoblast was found negetively correlated with Bax (P<0. 05). Conclusions:The increased Activin A in maternal and cord serum, as well as the increased expression of Bax and decreased expression of XIAP in placenta, may play important roles in the pathogenisis of IFGR. The increased Activin A may lead to excessive apoptosis of placental syncytiotrophoblast, which could impact the development and function of placenta and impede the fetal growth, by means of up-regulating expression of Bax and down-regulating expression of XIAP in IFGR.关键词
特发性胎儿生长受限/合体滋养细胞/激活素A/B细胞淋巴瘤因子相关x蛋白/X-连锁凋亡抑制蛋白Key words
Idiopathic fetal growth restriction/Syncytiotrophoblast/Activin A/B-cell lymphoma associated x protein/X-linked inhibitor of apoptosis protein分类
医药卫生引用本文复制引用
崔世红,张婷,刘萍萍,程国梅,贾国占,管秀娟,韩笑..激活素A、Bax和XIAP在特发性胎儿生长受限患者的表达及意义[J].实用妇产科杂志,2012,28(3):211-214,4.基金项目
河南省教育厅科技攻关项目(编号:2010A320021) （编号:2010A320021）
