实用妇产科杂志2012，Vol.28Issue(3)：215-218,4.
FISH快速检测自然流产绒毛染色体非整倍体异常的临床价值
Rapid Detection of Chromosomal Aneuploidy in Chorionic Villus of Spontaneous Abortion by Fluorescence in Situ Hybridization
吴庆华 1史惠蓉 1解艳华 1江淼 1赵振华 1鲁宁 1孔祥东1
作者信息
- 1. 郑州大学第一附属医院,河南郑州450052
- 折叠
摘要
Abstract
Objective;To evaluate the application of fluorescence in situ hybridization (FISH) for the detection of chromosomal aneuploidy in chorionic villus of spontaneous abortion. Methods:Thirty cases of chori-onic villus were analyzed by FISH, and seven probes were used to detect chromosomes 13, 16, 18, 21, 22, X, Y respectively. Results:In the thirty cases, seventeen cases were shown abnormal signals by FISH with detection rate of 57%, including eight cases of 16-trisomy, two cases of 22-trisomy, two cases of 13-trisomy and five cases of triploidy. Conclusions:FISH analysis is a rapid and easy method in the detection of chromosomal aneuploidy in chorionic villus. The application of FISH can provide important information of genetic counseling for the patients with spontaneous abortion.关键词
荧光原位杂交/自然流产/绒毛组织/染色体非整倍体Key words
Fluorescence in situ hybridization/Spontaneous abortion/Chorionic villus- Aneuploidy分类
医药卫生引用本文复制引用
吴庆华,史惠蓉,解艳华,江淼,赵振华,鲁宁,孔祥东..FISH快速检测自然流产绒毛染色体非整倍体异常的临床价值[J].实用妇产科杂志,2012,28(3):215-218,4.
