实用妇产科杂志2012，Vol.28Issue(3)：226-229,4.
人乳头瘤病毒分型检测在不同年龄CINⅡ～Ⅲ患者LEEP治疗后随访的临床研究
The Clinical Study of Subtypes Detection of HPV for Different Age Patients with Cervical Intraepithelial Neoplasia Ⅱ ～ Ⅲ after Loop Electrosurgical Excision Procedure
摘要
Abstract
Objective:To assess the clinical effectiveness and follow-up value by testing the clearance rate of human papillomavirus (HPV) after loop electrosurgical excision procedure (LEEP) treatment in different age patients with cervical intraepithelial neoplasia II~III (CIN II~III). Methods:336 cases with CIN ||~ III underwent loop electrosurgical excision procedure were enrolled. All patients were randomly assigned into three groups with each of 101 cases, according to different age, which were proved to be high risk HPVDNA infection preoperatively. Thin Prep liquid based cytology test (TCT) and HPVDNA detection were performed at 6th month postoperatively. The biopsies were done if necessary. The clearance and residual rate of HPVDNA were compared between groups. Results: ①The clearance rate of three groups after Leep was 93. 8%, 71. 4% and 64. 7% respectively . The clearance rate of HPV after Leep treatment was higher in the group ranging from 21 to 30 years old than that in the latter two groups( P<0. 05). There was no statistical difference between the latter two groups (P>0. 05). ②There were statistical differences in the group of 41 to 50 years old groups in persistent HPV16 infection, when compared to the group of 21 to 30 years old groups (P<0. 05). However there was no statistical difference in persistent HPV16 and other HPV subtypes infections (P>0. 05). ③The residual rate of persistent HPV16 infection in 41 to 50 years old group was higher as compared to 21 to 30 years old group ( P<0. 05). Conclusions:Leep is a simple and safe method that caneffectively resect cervical lesion while clear HPV. We suggest the follow up patients by six-month repeat HPVsubtypes detection for the women after Leep. Also, it is reasonable to propose a longer and closer fellow-upin 41 to 50 years old age population with persistent HPV16 infection after Leep.关键词
宫颈上皮内瘤变/人乳头瘤病毒/高频电刀锥切术Key words
Cervical intraepithelial neoplasia/Loop electrosurgical excision procedure/Human papillo-mavirus分类
医药卫生引用本文复制引用
杜蓉,陈志芳,韩英,丁岩..人乳头瘤病毒分型检测在不同年龄CINⅡ～Ⅲ患者LEEP治疗后随访的临床研究[J].实用妇产科杂志,2012,28(3):226-229,4.基金项目
国家自然科学基金资助(编号:81101555) （编号:81101555）
