兔动脉粥样硬化组织mPGES-1、L-PGDS的表达及辛伐他汀预处理对其表达的影响OA北大核心CSTPCD
Effects of simvastatin capsule on the expression of mPGES-1 and L-PGDS in the rabbit artery atherosclerotic tissue
目的:探索辛伐他汀对兔动脉粥样硬化组织1型膜相关前列腺素E合成酶(mPGES-1)、LiDocalin型前列腺素D合成酶(L-PGDS)表达的影响.方法:32只雄性新西兰大白兔,随机分为4组:A组为正常组:B组为模型对照组;C、D组分别为小剂量及大剂量辛伐他汀干预组;每组均为8只.药物治疗4周后取主动脉弓HE染色和RT-PCR检测mPGES-1、L-PGDS的表达.结果:(1)与A组比较B、C、D组mPGES-1、L-PGDS表达显著升高(P&l…查看全部>>
Objectives The aim of this study is to explore the effect of simvastatin capsule on the expression of membrane associated prostagladin E synthase-1 (mPGES-1) and lipcalin-type PGD synthase (L-PGDS) in the rabbit artery atherosclerotic tissue. Methods Thirty-two male New Zealand White Rabbits were randomly assigned into four groups: normal control group (group A), mode group (group B), group C and group D. Rabbits in group C were subsequently treated with min…查看全部>>
李文龙;李新华;刘恒方;张普;邹永伟
450052,郑州大学第五附属医院心内科450052,郑州大学第五附属医院心内科450052,郑州大学第五附属医院心内科450052,郑州大学第五附属医院心内科450052,郑州大学第五附属医院心内科
动脉粥样硬化Lipocalin型前列腺素D合成酶1型膜相关前列腺素E合成酶动物模型
Atherosclerosis Lipcalin-type PGD synthase Prostagladin E synthase-1 Animal model
《实用医学杂志》 2012 (8)
1251-1253,3
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