实用医学杂志2012，Vol.28Issue(8)：1304-1307,4.DOI:10.3969/j.issn.1006-5725.2012.08.032
原发性急性髓系白血病预后相关因素分析
Analysis of prognostic factors of de novo acute myeloid leukemia
摘要
Abstract
Objective To analyze the prognostic factors of de novo acute myeloid leukemia (AML), and provide clinical evidence for improving patient,s prognosis and prolonging their survival. Methods 109 patients with de novo AML (except AML-M3), who were admitted to Zhujiang Hospital from June 2006 to December 2010, were enrolled in this study. The Kaplan-Meier method was used to estimate overall survival (OS) and relapse-free survival (RFS). A single-factor analysis of prognostic factors of AML was done by using the log-rank test. Prognostic factors for survival were analyzed in a multiple, multivariate Cox regression model for OS. All statistical analysis were performed in SPSS Version 13.0. Results The complete remission (CR) ratio was 56.88%. The median OS and RFS were 9.5 and 5.5 months, respectively. The factors such as age > 60 years, high-risk cytogenetic subgroup and failing to achieve CR after first induction chemotherapy had poor influence on OS and RFS (P < 0.05). Conclusions The prognosis of patients with AML can be assessed according to these prognostic factors. The individual therapy concerning the risk factors should be applied for improving survival.关键词
白血病/髓样/急性/粒细胞/原发/预后因素Key words
Leukemia, myeloid, acute/ Granulocyte/ De novo/ Prognostic factor引用本文复制引用
武玉慧,涂三芳,郭坤元,李玉华..原发性急性髓系白血病预后相关因素分析[J].实用医学杂志,2012,28(8):1304-1307,4.基金项目
国家自然科学基金(编号:30500607) （编号:30500607）
教育部新世纪优秀人才支持计划(编号:NCET-09-0087) （编号:NCET-09-0087）
广东省自然科学基金重点项目(编号:9251051501000007) （编号:9251051501000007）
