实用医学杂志2012，Vol.28Issue(8)：1343-1345,3.DOI:10.3969/j.issn.1006-5725.2012.08.049
新序贯疗法与三联疗法治疗幽门螺杆菌阳性萎缩性胃炎的疗效比较
Comparison of a new sequential therapy and triple therapy on patients of atrophic gastritis with Helicobacter pylori infection
刘艳 1胡红松 1李学锋 1黄妙娟 1陈晓红 1黄素娴 1俞红华1
作者信息
- 1. 518172,广东省深圳市龙岗区人民医院消化内科
- 折叠
摘要
Abstract
Objective To compare the therapeutic effects of a new sequential therapy and triple therapy on patients of atrophic gastritis with Helicobacter pylori(Hp ) infection. Methods 80 patients of atrophic gastritis with Hp infection were randomly divided into 2 groups: treated group and control group. 40 cases of treated group took a new sequential therapy , which consisted of a 10 day treatment including esomeprazole 20 mg bid plus amoxicillin 1 000 mg bid for the first 5 days, followed by esomeprazole 20 mg bid, levofloxacin 200 mg bid and furazolidone 100 mg bid for the next 5 days. 40 cases of control group took esomeprazole 20 mg bid, amoxicillin 1 000 mg bid, levofloxacin 200 mg bid for 7 days. Two groups were compared with differences of symptom scale scores^Hp eradication rates and histopathological changes after 3 months. Results There was significant difference in total effective rate between treated group ( 87.50%) and control group (70.00%) (P < 0.05). The Hp eradication rate of treated group was 92.50% and 80.00% in control group,and there was significant difference between the two groups (P< 0.05). The symptom scale scores^histopathological scores and gastric atrophy of the treatment group were better than those of control group(P < 0.05). Conclusion The new sequential therapy including esomeprazole, amoxicillin, levofloxacin and furazolidone has a better Hp eradication effect for Hp positive atrophic gastrits patients than standard triple therapy ; the clinical symptoms and gastric atrophy can be greatly improved after Hp eradication.关键词
萎缩性胃炎/序贯疗法/幽门螺杆菌/左氧氟沙星/呋喃唑酮Key words
Atrophic gastrits/ Sequential therapy/ Helicobacter pylori/ Levofloxacin/ Furazolidone引用本文复制引用
刘艳,胡红松,李学锋,黄妙娟,陈晓红,黄素娴,俞红华..新序贯疗法与三联疗法治疗幽门螺杆菌阳性萎缩性胃炎的疗效比较[J].实用医学杂志,2012,28(8):1343-1345,3.
