实用肿瘤杂志2012，Vol.27Issue(3)：233-236,4.
凋亡相关分子在非小细胞性肺癌与癌旁组织中的表达及其意义
Expression of apoptotic signal molecules in NSCLC and adjacent tissues and its significance
摘要
Abstract
Objective To investigate the expressions of the pro-apoptotic signal molecules CASP3, CASP8, CASP9 and anti-apoptotic signal molecules Bcl-2 and XIAP in lung cancer and their potential significance. Methods Twenty-six cases of paired cancer versus adjacent non-cancerous tissues, formalin-fixed paraffin-embedded, of NSCLC were collected and made into tissue microarray (TMA) with tissue microarrayer of Beecher Instruments. Immunohistochemistry (IHC) was performed to analyze the expression levels of CASP3, CASP8, CASP9, XIAP and Bcl-2. Results In the evaluable 25 cases of paired cancer versus adjacent tissues, paired sample t lest showed that CASP8 was not significantly differentially expressed between cancer and adjacent tissues (P >0.05) , other molecules CASP3, CASP9, XIAP and Bcl-2 all expressed in cancers at a higher level than those in adjacent tissues (P<0.01). Bi-variale correlation analysis primarily found significant correlation between Bcl-2 expression in adjacent tissues and CASP8 in adjacent tissues (r = 0.490, P = 0.015), and between CASP3 expression in cancers with CASP9 expression in cancers (r = 0.575, P = 0.003). Conclusions The expressions of the pro-apoptotic signal molecules and anti-apoptotic signal molecules in lung cancer are both up-regulated, CASP3 and Bcl-2 might be of clinical implication as potential target to induce tumor cell apoptosis. Significant correlation between Bcl-2 and CASP8 in adjacent tissues and between CASP3 and CASP9 in cancer tissues suggests that these molecules might have potential functional interaction.关键词
肺肿瘤/细胞凋亡/组织芯片/免疫组织化学Key words
lung neoplasms/ apoptosis/ tissue microarray/ immunohistochemisty分类
医药卫生引用本文复制引用
梁红玲,黄健清,张绪超,谢至,陈世良,苏健,郭伟浜..凋亡相关分子在非小细胞性肺癌与癌旁组织中的表达及其意义[J].实用肿瘤杂志,2012,27(3):233-236,4.基金项目
国家自然科学基金(No:30772531) （No:30772531）
