生殖医学杂志2012，Vol.21Issue(2)：111-115,5.DOI:10.3969/j.issn.1004-3845.2012.02.005
促性腺激素的同分异构体
FSH isomer and ovarian response
孙瑜 1朱依敏1
作者信息
- 1. 浙江大学医学院附属妇产科医院生殖中心,杭州 310006
- 折叠
摘要
Abstract
Follicle stimulating hormone(FSH) is an important reproductive hormone in human, the FSH isomers have variable biological properties, which can affect the ovarian function through interaction with FSH receptors. Ovarian response to FSH stimulation also depends on FSH receptor genotype. At present,a large number of single nucleotide polymorphisms(SNPs) were investigated in FSH receptors genes, which may cause the difference of ovarian function through the influencing on receptor activities and may be related with ovarian stimulus response in assisted reproductive technology. The determination of gene polymorphism in patients with ovarian stimulation show significances in making the individual programs of ovarian stimulation, which can optimize the treatment of infertility. However more clinical trials are needed to confirm its effectiveness.关键词
卵泡刺激素同分异构体/卵泡刺激素受体基因突变/卵泡刺激素受体基因多态性/卵巢反应Key words
FSH isomers/FSHR gene mutation/FSHR gene polymorphisms/Ovarian response引用本文复制引用
孙瑜,朱依敏..促性腺激素的同分异构体[J].生殖医学杂志,2012,21(2):111-115,5.
