生殖医学杂志2012，Vol.21Issue(2)：149-153,5.DOI:10.3969/j.issn.1004-3845.2012.02.015
体外受精-胚胎移植周期应用黄体酮胶囊进行黄体支持的临床研究
Effect of vaginal progesterone supplementation in luteal phase in IVF-ET cycles
张宁 1郝翠芳 1单英华 1庄丽丽 1曲庆兰1
作者信息
- 1. 山东省烟台毓璜顶医院生殖医学中心,烟台264000
- 折叠
摘要
Abstract
Objective: To analyze the effect of vaginal capsule of micronized progesterone supplementation during luteal phase in IVF-ET cycles.Methods: A total of 769 IVF cycles used progesterone supplementation were evaluated retrospectively. The patients were divided into 6 groups according to the regimen of progesterone supplementation in luteal phase. One hundred and forty IVF cycles were administrated vaginal capsule of progesterone in group A, 53 cycles intramuscular (IM) injection of progesterone in group B, 228 cycles vaginal capsule of progesterone and hCG on day 5 after embryo transfer (ET) in group C, 85 cycles IM progesterone and hCG on day 5 after ET in group D, 161 cycles vaginal capsule of progesterone and hCG on day 7 after ET in group E, 102 cycles IM progesterone and hCG on day 7 after ET in group F.Results; During the luteal phase, the progesterone levels were lower in the groups used vaginal capsule of progesterone than those used IM progesterone on day 5 after ET. The progesterone levels were significantly lower in Group C than those in Group D [(71. 96 + 36. 11) nmol/L vs. (83. 34 + 23. 30) nmol/ L,-x±s](P<0. 01), and they were significantly lower in Group E than in Group F [(130. 45 + 56. 46) nmol/L vs. (144. 93±46. 09) nmol/L ](P<0. 05). The progesterone levels on day 7 after ET in Group E were significantly lower than in Group F[(59. 66 + 29. 01) nmol/L vs. (80. 01 + 24. 28) nmol/L](P< 0. 01). The implantation rate of women used vaginal capsule of progesterone was significantly higher than that with IM progesterone (43. 7% vs 33. 8%, P<0. 01), but there were no significant differences in pregnancy rate and miscarriage rate (58. 4% vs 53. 3%, P = 0. 21; 2. 9% vs 6. 3% P = 0. 11, respectively).Conclusions: It is suggested that the supplementation of vaginal micronized progesterone is reasonable for luteal support in women undergoing IVF-ET with gonadotropin-releasing hormone agonist (GnRH-a) long protocol.关键词
体外受精/黄体支持/黄体酮/妊娠率/种植率Key words
In-vitro fertilization/ Luteal phase support/ Progesterone/ Pregnancy rate/ Implantation rate引用本文复制引用
张宁,郝翠芳,单英华,庄丽丽,曲庆兰..体外受精-胚胎移植周期应用黄体酮胶囊进行黄体支持的临床研究[J].生殖医学杂志,2012,21(2):149-153,5.
