三峡大学学报（自然科学版）2012，Vol.34Issue(2)：83-85,3.
开口箭醇提物抗慢性咽炎活性研究
Tupistra Alcohol Extract Activity of Anti-Chronic Pharyngitis
摘要
Abstract
In order to investigate the mechanism of Tupistra alcohol extract in treating chronic pharyngitis, effects of Tupistra alcohol extract on TL-1|3 and TNF-a in the serum were observed in the rats with chronic pharyngitis. 48 Wistar rats were divided into 6 groups, namely the normal control group, large-dose Tupistra alcohol extract group, small-dose Tupistra alcohol extract group, model control group, Xiguashuang group, and each group consisted of 8 rats. The rat model of chronic pharyngitis was induced by spraying the larynx with strong ammonia water. Distilled water, large dose of Tupistra alcohol extract solution (0. 32g/kg) , middle dose of Tupistra alcohol extract solution (0. 24g/kg) , small dose of Tupistra alcohol extract solution (0. 16g/kg) and Xiguashuang solution (1. 4Og/kg) were respectively given to the animals in each corresponding group. On the 47th day of the experiment , the levels of IL-1(B and TNF-Q in the serum were detected in the blood of the femoral vein of the animals in the 5 groups, respectively, and at the same time, the pharyngeal mucosal and submucosal tissues of the animals were also examined pathomorphologically. The results showed that both large dose and small dose of Tupistra alcohol extract could effectively decrease the percentage of blood lymph cells and the levels of IL- 6 and TNF-a in the serum * and improve the pathologic picture of thepharyngeal tissues in the model animals.关键词
开口箭醇提物/慢性咽炎/白细胞介素-1β/肿瘤坏死因子-αKey words
Tupistra chinensis/ chronic pharyngitis/ Interleukin-1(3/ Tumor necrosis factor-a分类
医药卫生引用本文复制引用
邬昊洋,周园,李诺飞,贺海波,邹坤..开口箭醇提物抗慢性咽炎活性研究[J].三峡大学学报（自然科学版）,2012,34(2):83-85,3.基金项目
国家自然科学基金(30870254,31070313) （30870254,31070313）
