物理化学学报2012，Vol.28Issue(4)：897-902,6.DOI:10.3866/PKU.WHXB201202091
微乳液法制备可共载水溶和脂溶药物的壳聚糖季铵盐乙醇脂质体的载药性能表征
Characterization of Chitosan Polymeric Ethosomes Capable of Encapsulating Hydrophobic and Hydrophilic Drugs Prepared by a Microemulsion Method
摘要
Abstract
Polymeric ethosomes,formed from amphiphilic octadecyl quaternized carboxymethyl chitosan (OQCMC) with different degrees of quaternary substitution (DS),were prepared by the microemulsion (ME) method.These ethosomes could simultaneously encapsulate both the hydrophobic drug indomethacin (IMC) and the hydrophilic drug vincristine (VCR).The effects of the DS of the OQCMC and primary alcohols as cosurfactants on the phase diagram were elucidated.The prepared nanoparticles (NPs) were small ((52.40± 0.55) nm) and suitable as drug carriers for different drugs.The maximum drug loading efficiencies of VCR-loaded and IMC-Ioaded NPs were 22.7％ and 20.1％,respectively.The drug loading capacities for co-delivery of VCR and IMC were 12.2％ and 10.0％,respectively.OQCMC polymeric ethosomes were stable in aqueous solution and exhibited slow,steady drug release.Hydrophilic fluorescein isothiocyanate (FITC) and hydrophobic Nile Red were encapsulated by the OQCMC ME NPs and simultaneously delivered into HO8901 cells with green and red fluorescence,respectively.This co-delivery system may allow for temporally distinct classes of drugs for cancer therapy.关键词
壳聚糖/表面活性剂/纳米颗粒/药物递送/微乳液/乙醇脂质体Key words
Chitosan/Surfactant/Nanoparticie/Drug delivery/Microemulsion/Ethosome分类
化学化工引用本文复制引用
梁晓飞,胡晶莹,陈复华,李宗海,常津..微乳液法制备可共载水溶和脂溶药物的壳聚糖季铵盐乙醇脂质体的载药性能表征[J].物理化学学报,2012,28(4):897-902,6.基金项目
国家自然科学基金(51003059)及上海市自然科学基金(12OZR1428900)资助项目 （51003059）
