现代妇产科进展2012，Vol.21Issue(3)：175-178,4.
LMP基因多态性及其在母胎间共享与子痫前期相关性研究
Association of LMP gene polymorphism and it's feto-mother sharing with severe pre-eclampsia
张嵩卉 1高眉扬 1田耕 1张兰珍 1廖志琼1
作者信息
- 1. 广州医学院第二附属医院产科,广州 510260
- 折叠
摘要
Abstract
Objective: To explore whether the polymorphism of large multifunctional protease ( LM P) gene in mothers and fetus have any relations with severe pre-eclampsia. To investigate the associations of the LMP gene sharing in feto-mothers with severe pre-eclampsia. Methods;The LMP2 and LMP7 gene polymorphisms were determined by RFLP respectively in 77 severe pre-eclampsia mothers and their fetus,and in 200 healthy controls. All of them were taken treatments in our hospital from July. 2006 to Aug. 2010. Results: ( 1 ) The frequency of LMP2-R/R,LMP7-B/B were significantly lower in the severe pre-eclampsia gravida compared with the healthy controls ( P＜0. 05 , OR = 0. 211,0. 238 respectively) , but the frequency of LMP2-R/H was higher(P＜0.05,OR = 4. 594). (2)There were no significant difference among fetus between the severe pre-eclampsia subgroup and the healthy controls in all of the twelve al-leles of LMP2 and LMP7(P＞0. 05). (3) The percentage of having only one genotype sharing ratio was lower in severe pre-eclampsia groups,and the four genotypes sharing ratio was higher in severe pre-eclampsia group(P＜0.05 ,OR = 0.051,5.36 respectively). Conclusions; LMP2-R/H is like to be a susceptible gene for pre-eclampsia,while LMP2R/R and LMP7-B/B have protective effect against pre-eclampsia. The high sharing rates of LMP genotypes between the mothers and their fetuses showed a independent factor to PE.关键词
子痫前期/巨大多功能蛋白酶体/等位基因/基因多态性/基因共享/遗传免疫Key words
Pre-eclampsia/Large multifunctional protease/Alleles/Gene polymorphism/Gene sharing/Immunogenetics分类
医药卫生引用本文复制引用
张嵩卉,高眉扬,田耕,张兰珍,廖志琼..LMP基因多态性及其在母胎间共享与子痫前期相关性研究[J].现代妇产科进展,2012,21(3):175-178,4.
