现代妇产科进展2012，Vol.21Issue(3)：179-181,185,4.
胚胎停育绒毛组织中TGF-β1、MMP-9及TIMP-1的表达及意义
Study on expression of TGF-β1, MMP-9 and TIMP-1 in the chorionic villi of early embryo growth arrest
摘要
Abstract
Objective:To study on expression of TGF-β1, MMP-9 and TIMP-1 mRNA in the chorionic villi of early embryo growth arrest and to evaluate the mechanism of early embryo growth arrest. Methods: Reverse transcription polymerase chain reaction ( RT-RCR) was used on the normal groups ( 20 cases ) and the early embryo growth arrest group ( 25 cases) to quantitatively determining TGF-|31 , MMP-9 and TIMP-1 mRNA in the chorionic villi tissues. And their quantities were noted by the density of TGF-β1/β-actin MMP-9 /β-aetin or TIMP-1/ (3-aetin. Results: (1)Compare with the normal group, the mRNA expression levels of TGF-β and TIMP-1 of early embryo growth arrest was lower( P＜0. 05 ) , while the levels of MMP-9 was significantly higher(P＜0. 05 ). (2) There was a negative correlation between the TGF-β1 and MMP-9 in chorionic villi tissues(r = -0. 82,P＜0.05). Conclusions:The abnormal expression of the TGF-β1 , MMP-9 and TIMP-1 are already changed at the level of transcription. TGF-β1 may,by increasing the expression of MMP-9, leads to the destroy the dynamic equilibrium MMPs/TIMPs,and might be involved in the pathogesis of early embryo growth arrest.关键词
胚胎停育/绒毛组织/TGF-β1/MMP-9/TIMP-1Key words
Early embryo growth arrest/Chorionic villi tissues/TGF-β1 /MMP-9/TIMP-1分类
生物科学引用本文复制引用
栾丽霞,朱晓明,马媛,李怡,王珺,尹国武..胚胎停育绒毛组织中TGF-β1、MMP-9及TIMP-1的表达及意义[J].现代妇产科进展,2012,21(3):179-181,185,4.基金项目
国家自然科学基金资助项目(No:30973208、No:31000660) （No:30973208、No:31000660）
