中国组织工程研究2012，Vol.16Issue(19)：3584-3587,4.DOI:10.3969/j.issn.1673-8225.2012.19.032
脐血干细胞移植治疗脑卒中的作用与机制
Effect and mechanism of umbilical cord blood stem cells transplantation in the treatment of stroke
赵红 1王苏平1
作者信息
- 1. 大连中心医院神经内科,辽宁省大连市,116033
- 折叠
摘要
Abstract
BACKGROUND: Many basic and clinical studies have shown that umbilical cord blood stem cells (UCBSCs) transplantation can improve neurological function after focal cerebral ischemia.OBJECTIVE: To summarize the related research and the underlying mechanism of UCBSCs transplantation in the treatment of stroke.METHODS: The first author retrieved PubMed database and Wanfang database for articles of basic research on UCBSCs transplantation for cerebral ischemia published from January 2001 to August 2011. The key words were "umbilical cord blood stem cells, focal cerebral ischemic, transplantation" in English and Chinese. A total of 50 relevant literatures were retrieved, and finally, 30 articles were included according to the inclusion criteria.RESULTS AND CONCLUSION: UCBSCs could be differentiated into nerve cells in appropriate induced conditions with the characters of self-renewal, proliferation, and multi-directional differentiation potential. Related studies had indicated that UCBSCs transplantation could improve neurological disorder and decrease damaged infarct volume. The mechanisms include reducing inflammation, increasing trophic factor secretion, and promoting angiogenesis and nerve fiber reorganization. Greater achievements have been made in the treatment of stroke, but many problems still existed. Some problems need further investigation, for example, how to improve the utilization rate of UCBSCs, prevent excessive cell proliferation and whether these cells can be integrated into the injury site to preserve normal function.关键词
脐血干细胞/局灶性脑缺血/脑卒中/移植/综述文献分类
医药卫生引用本文复制引用
赵红,王苏平..脐血干细胞移植治疗脑卒中的作用与机制[J].中国组织工程研究,2012,16(19):3584-3587,4.
