中国组织工程研究2012，Vol.16Issue(20)：3779-3783,5.
CDKAL1基因rs7754860位点G《C多态性与2型糖尿病易感关系的Meta分析
Meta-analysis on CDKAL1 gene rs7754860 single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility
摘要
Abstract
BACKGROUND: The pathogenesis of type 2 diabetes is unclear, and genetic studies have shown that there may be geneticpredisposition, but the results are not consistent with each other.OBJECTIVE: To evaluate the relationship between cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1) gene rs7754860 G<C single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility.METHODS: By searching EMBSE (1974/2011-05), PubMed (1966/2011-05), CNKI (1994/2011-05) and CBM (1978/2011-05),we collected studies about CDKAL1 gene rs7754860 G<C single neucleotide polymorphisms and type 2 diabetes mellitussusceptibility. The odds ratios (OR) of variant allele of CDKAL1 gene rs7754860 was calculated by using Review Manager 5.0software.RESULTS AND CONCLUSION: A total of 19 03 cases and 22 560 controls were included in nine case-control studies. The riskfor type 2 diabetes mellitus was higher in the CC group compared with GG group (OR=1.51, 95% confidence interval (CI):1.24-1.84, P < 0.01); For the dominant genetic model, the risk for type 2 diabetes mellitus had no significant difference betweenthe CC+GG group and GG group (OR=1.22, 95%CI: 0.95-1.56, P=0.12). For the recessive genetic model, the risk for type 2diabetes mellitus in the CC group was significantly increased as compared with the GC+GG group (OR=1.61, 95%CI: 1.41-1.83,P < 0.01). CDKAL1 gene rs7754860 C<G single neucleotide polymorphisms has close relationship with type 2 diabetes mellitussusceptibility. People with C allele are susceptible to type 2 diabetes mellitus.关键词
单核苷酸多态性/2型糖尿病/CDKAL1基因/Meta分析分类
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王娟,陈莉明,孙红喜,郭俊,温娟娟..CDKAL1基因rs7754860位点G《C多态性与2型糖尿病易感关系的Meta分析[J].中国组织工程研究,2012,16(20):3779-3783,5.基金项目
国家自然科学基金资助项目(81072922). （81072922）
