中国组织工程研究2012，Vol.16Issue(20)：3793-3796,4.
血小板裂解液在骨组织工程中的应用
Platelet lysate's advances in bone tissue engineering
陈璐 1李琪佳 1宋会平1
作者信息
- 1. 河北联合大学中心实验室,河北省唐山市,063000
- 折叠
摘要
Abstract
BACKGROUND: Platelet lysates to repair bone defects cannot only remove the residual cell structure, reduce immunogenicity,but also retain many growth factors to create the conditions for the allograft or xenograft.OBJECTIVE: To review the studies that platelets can promote the growth of bone lysis as well as application methods in relevantresearch.METHODS: PubMed (2004-01/2011-01) and CBM databases (2004-01/2011-01) were searched by using the keywords of"tissue engineering, bone defect, gene therapy, growth factor" in English and "platelet plasma, bone tissue engineering, plateletlysate, growth factor" in Chinese, respectively. Studies addressing platelet lysate to promote bone regeneration and repair wereincluded, and repetitive studies were excluded.RESULTS AND CONCLUSION: Totally 340 articles were retrieved, and only 23 articles met the inclusive criteria. Up to now,studies have demonstrated that platelet lysate can promote the proliferation of bone marrow mesenchymal stem cells andosteoblasts. Platelet lysate combined with biological ceramic or autogenous bone can significantly promote the repair of bonedefects. Rational use of platelet lysate in bone regeneration and repair is of great significance.关键词
血小板裂解液/成骨细胞/骨缺损/细胞生长因子/骨组织工程分类
医药卫生引用本文复制引用
陈璐,李琪佳,宋会平..血小板裂解液在骨组织工程中的应用[J].中国组织工程研究,2012,16(20):3793-3796,4.
