中国组织工程研究2012，Vol.16Issue(20)：3797-3800,4.
腺病毒介导的骨形态发生蛋白基因增强在骨组织工程中的应用
Application of adenovirus mediated bone morphogenetic protein gene enhanced tissue engineering in bone tissue engineering
潘乐 1康建敏2
作者信息
- 1. 石家庄学院体育系,河北省石家庄市,050035
- 2. 河北经贸大学体育教学部,河北省石家庄市,050061
- 折叠
摘要
Abstract
BACKGROUND: The vector tool is needed when the target gene transduces into target cells, the vector can help the gene transduces into the cells and promote the protein expression. Vector selection is the key of the gene transduction. OBJECTIVE: To review research progress of the application of adenovirus medicated bone morphogenetic protein gene enhanced tissue engineering in osteogenic induction and repair of bone defects.METHODS: A computer-based search was performed on the PubMed database and CNKI database from January 1989 to January 2012 for the articles on the osteogenic induction of adenovirus medicated bone morphogenetic protein gene transfection and the articles on bone morphogenetic protein gene modified tissue engineered bone repair the bone defects. The key words were "adenovirus, bone morphogenetic protein, gene transfection, bone tissue engineering" in English and Chinese. The repetitive articles and the articles not in English or Chinese were eliminated, and finally, a total of 24 articles were included to review.RESULTS AND CONCLUSION: Adenovirus-mediated bone morphogenetic protein gene enhanced tissue engineering transfers the gene encoding with specific function factor to the seed cells using genetic engineering technology, which make the gene to produce the growth factor continuously. Transgenic cells stay on the surface of the stent and release the growth factor slowly, and can promote the proliferation and differentiation of osteoblast precursor cells and induce the directed differentiation of the osteoblast precursor cells in the bone defect area to osteoblasts, in order to repair the bone defects.关键词
骨形态发生蛋白/腺病毒/基因转染/骨组织工程/综述文献分类
医药卫生引用本文复制引用
潘乐,康建敏..腺病毒介导的骨形态发生蛋白基因增强在骨组织工程中的应用[J].中国组织工程研究,2012,16(20):3797-3800,4.
