中国组织工程研究2012，Vol.16Issue(21)：3886-3890,5.DOI:10.3969/j.issn.1673-8225.2012.21.020
磁悬浮离心式心室辅助装置的体外溶血测试
In vitro hemolysis test of a maglev centrifugal ventricular assist device
摘要
Abstract
BACKGROUND: Ventricular assist devices are widely used in patients with heart failure. Although different blood pumps havebeen developed and used throughout the world, few blood pumps are used in China because of the high prices. Development of aless expensive pump for clinical use is urgently needed in China.OBJECTIVE: To test the hemolytic characteristics of an implantable magnetic suspension centrifugal ventricular assist devicein vitro.METHODS: The flow field of the blood pump was analyzed with the computational fluid dynamics. Blood pumps were connected ina mock circulatory loop, filled with fresh sheep blood, and the pump generated 5 L/min flow against a head pressure of 100 mm Hg(1 mm Hg=0.133 kPa). The in vitro hemolytic properties were evaluated by determining the level of plasma free hemoglobin atdefined intervals.RESULTS AND CONCLUSION: Based on the computational fluid dynamics, a stable blood flow line was shown inside the pump,the wall shear stress inside the pump was less than 68.5 Pa and the internal static pressure distribution was smooth withoutadverse area. The normalized index of hemolysis was (0.075±0.017) mg/L. The blood pump showed satisfactory hemolyticproperties as compared with the other third generation pumps. No mechanical failure occurred during the experiments. Therefore,long-term in vivo circulation assist experiment of the new blood pump could be carried on to evaluate its hemodynamics andend-organ effect in the future.关键词
离心血泵/心室辅助装置/磁悬浮/溶血实验/计算流体力学分类
医药卫生引用本文复制引用
吴广辉,蔺嫦燕,陈琛,杨鹏,渠文波,姚凌飞,王璟..磁悬浮离心式心室辅助装置的体外溶血测试[J].中国组织工程研究,2012,16(21):3886-3890,5.基金项目
国家高技术研究发展计划项目(863计划,2009AA045401) （863计划,2009AA045401）
北京市自然基金资助项目(3112011). （3112011）
