摘要
Abstract
BACKGROUND: Due to the characteristics of short half-life, fast metabolism and direct effect to the tumor cells, controlledrelease formulation is applied to anti-tumor treatment. Fluorouracil controlled release formulation is characterized by long-termdrug action, maximum drug concentration in the area of the target lesion, low systemic adverse reaction, as well as low damageto the liver.OBJECTIVE: Using literature search and the depth of analysis capabilities of Wanfang database, to analyze the data trends inthe study of fluorouracil controlled release formulation, and to explore the safety after its implantation.DESIGN: Bibliometric data analysis.DATA RETRIEVAL: A search of related literature of fluorouracil controlled release formulation was performed in Wanfangdatabase, with key words of "controlled release formulation", "fluorouracil", "antineoplastic" and "biomaterial", from 2002-01 to2011-12. The retrieval results were analyzed, and the trends were described in words and graphics.SELECTION CRITERIA: Inclusive criteria: ?Basic research papers related to fluorouracil controlled release formulation.?Papers related to the controlled release formulation for anti-tumor treatment. ?Papers related to the security issues afterimplantation of fluorouracil controlled release formulation. Exclusive criteria: ?Literature has nothing to do with the purpose ofthis review. ?Duplication of research literature. ?Journal's own information. ?Unpublished papers. ?The article needs to beretrieved by phone or manual searches. ?The literature focuses on nursing.MAIN OUTCOME MEASUREMENTS: The literatures were analyzed by data trends published year, literature number, subjectcategory, research institutions, source journals, literature citations, literature download frequency, associated literature,distribution of the author, distribution of the funding and major keywords. The Ph.D. Thesis, outstanding master's degree papers,conference papers, and the clinical applications of fluorouracil controlled release formulation were analyzed as well as the safetyafter implantation.RESULTS: A total of 49 research literatures related to fluorouracil controlled release formulation were retrieved in Wanfangdatabase during 2002-2011. The number of papers was in the steady state. Most of literatures were published in 2008 (n=8). Andthe literatures were focused on pharmaceutical discipline. Zhongguo Yiyao Gongye Zazhi published more literatures than others.A total of 32 projects were supported by funding, and most of them supported by the National Natural Science Foundation ofChina. The frequently used subject words and key words are "fluorouracil", "chitosan" and "nanoparticles", respectively. In manyliteratures, chitosan is selected as a carrier, and fluorouracil-loaded chitosan nanoparticle for drug delivery is the focus of thestudy. Fluorouracil controlled release formulation has a certain effect in the treatment of esophagus, cardia, gastric cancer, coloncancer, breast cancer, which is a safe and effective treatment.CONCLUSION: The bibliometric data analysis on fluorouracil controlled release formulation in Wanfang database and summaryon safety after implantation can provide valuable reference for Chinese medical workers in both basic research and clinical studyof anti-tumor controlled release formulation.关键词
缓释材料/缓释剂/氟尿嘧啶/抗肿瘤药/生物材料/文献计量分类
医药卫生
