中国组织工程研究2012，Vol.16Issue(23)：4290-4295,6.DOI:10.3969/j.issn.1673-8225.2012.23.022
自体骨髓间充质干细胞移植脑性瘫痪儿童运动功能的评价
Effect evaluation of autologous bone marrow mesenchymal stem cell transplantation on motor function in children with cerebral palsy
刘岩松 1王晓东 2杨静 2滑蓉蓉 2程洪斌 2刘亚飞 2安沂华3
作者信息
- 1. 辽宁医学院武警总医院研究生培养基地,北京市,100039
- 2. 武警总医院干细胞移植科,北京市,100039
- 3. 首都医科大学附属北京天坛医院,北京市神经外科研究所,北京市,100050
- 折叠
摘要
Abstract
BACKGROUND: Cerebral palsy is described as a group of permanent disorders affecting motor development and posture,resulting in activity limitation. Although there are many kinds of functional therapy programs for cerebral palsy, their effects arelimited. Stem cell based therapy, a new prospective therapy for central nervous system disorders, has the potential to repairand replace damaged brain tissue, and alleviate neurological deficits and motor function in cerebral palsy.OBJECTIVE: Using Gross Motor Function Measure-88 (GMFM88) and Fine Motor Function Measure-45 (FMFM45) scaleto evaluate the effect of autologous bone marrow mesenchymal stem cell transplantation on motor function in children withcerebral palsy.METHODS: Twenty cerebral palsy children received autologous bone marrow mesenchymal stem cell transplantation andtheir motor functions were measured using GMFM88 scale and FMFM45 at baseline (the day before treatment) and 1, 3and 6 months after treatment.RESULTS AND CONCLUSION: Seventeen subjects successfully accomplished the clinical study. Results of statisticalanalysis by SPSS13.0 software showed that (1) The A, B, C functional area scores and total score of GMFM88 increasedsignificantly at 1, 3 and 6 months after bone marrow mesenchymal stem cell transplantation than that at baseline (P <0.05). (2) The B, C functional area scores and total score of FMFM45 increased significantly at 1, 3 and 6 months afterbone marrow mesenchymal stem cell transplantation than that at baseline (P < 0.05). During the present study period, noevents had happened. Bone marrow mesenchymal stem cell transplantation is a safe, effective and feasible method totreat cerebral palsy patients. The gross and fine motor function was most rapidly improved in 1 month after the therapyand it could be continuously improved within 6 months after the therapy.关键词
脑性瘫痪/骨髓间充质干细胞/移植/粗大运动功能量表/精细运动功能量表分类
医药卫生引用本文复制引用
刘岩松,王晓东,杨静,滑蓉蓉,程洪斌,刘亚飞,安沂华..自体骨髓间充质干细胞移植脑性瘫痪儿童运动功能的评价[J].中国组织工程研究,2012,16(23):4290-4295,6.
