中国组织工程研究2012，Vol.16Issue(23)：4354-4358,5.DOI:10.3969/j.issn.1673-8225.2012.23.033
骨髓间充质干细胞移植治疗脊髓损伤的应用技术
Application of bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury
摘要
Abstract
BACKGROUND: At present, there lacks effective repair approach for atrophy and necrosis of spinal nerve of spinal cord injury patients in the clinic. Bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injuryhas wide application prospects.OBJECTIVE: To summarize the progress of bone marrow mesenchymal stem cells transplantation for the treatment ofspinal cord injury.METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database(http://g.wanfangdata.com.cn/) for literatures concerning bone marrow mesenchymal stem cells, spinal cord injury and celltransplantation from 2001 to 2011. Key words were “bone marrow mesenchymal cells, spinal cord injury, celltransplantation” in English. Duplicate articles were excluded. Finally, 32 articles were selected to summarize.RESULTS AND CONCLUSION: The research of bone marrow mesenchymal stem cells transplantation for treatment ofspinal cord injury has made achievements in the spinal cord injury model establishment, transplantation time andapproach, concentration and combined transplantation. Although clinical trials have been carried out at home and abroad,the mechanism was not very clear yet. The safety and efficacy of clinical treatment need further investigation.关键词
脊髓损伤/骨髓间充质干细胞/细胞移植/研究/治疗/干细胞分类
医药卫生引用本文复制引用
王格,武栋成..骨髓间充质干细胞移植治疗脊髓损伤的应用技术[J].中国组织工程研究,2012,16(23):4354-4358,5.基金项目
国家自然科学基金项目(面上项目,30670813). （面上项目,30670813）
