中国组织工程研究2012，Vol.16Issue(23)：4367-4370,4.DOI:10.3969/j.issn.1673-8225.2012.23.035
人脐血单个核细胞移植前后自闭症患儿脑脊液中细胞生长因子的表达
Changes in cellular growth factor levels in cerebrospinal fluid of autism patients before and after human umbilical cord blood mononuclear cell transplantation
李强 1安蕾 2吕涌涛 1郇英 1刘敏 1葛汝村 1陈兴旺 1齐宏顺 1高宝峰 1胡祥2
作者信息
- 1. 山东省交通医院干细胞与再生医学研究室,山东省济南市,250031
- 2. 深圳市北科生物科技有限公司,广东省深圳市,518057
- 折叠
摘要
Abstract
BACKGROUND: Studies have demonstrated that umbilical cord blood mononuclear cells exhibit some effects in treatment of autism.OBJECTIVE: To detect levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and basicfibroblast growth factor (bFGF) in cerebrospinal fluid of autism patients treated with umbilical cord blood mononuclearcells.METHODS: A total of 30 autism children received treatment by injection of human umbilical cord blood mononuclear cellsvia lumbar puncture subarachnoid cavity, once a week, for three times totally.RESULTS AND CONCLUSION: The levels of nerve growth factors were significantly greater at 1 week after thesecond treatment than pretreatment and 1 week after the first treatment (P < 0.05). The levels of vascular endothelialgrowth factors and basic fibroblast growth factors were slightly, but not significantly, higher at 1 week after the secondtreatment than pretreatment and at 1 week after the first treatment (P > 0.05). Results suggest that the levels of nervegrowth factors in cerebrospinal fluid were significantly increased in autism children who received treatment ofumbilical cord blood mononuclear cells, however, the levels of vascular endothelial growth factors and basic fibroblastgrowth factors were not influenced significantly.关键词
脐血/单个核细胞/儿童/自闭症/脑脊液/生长因子/干细胞分类
医药卫生引用本文复制引用
李强,安蕾,吕涌涛,郇英,刘敏,葛汝村,陈兴旺,齐宏顺,高宝峰,胡祥..人脐血单个核细胞移植前后自闭症患儿脑脊液中细胞生长因子的表达[J].中国组织工程研究,2012,16(23):4367-4370,4.
