中国组织工程研究2012，Vol.16Issue(24)：4453-4458,6.DOI:10.3969/j.issn.1673-8225.2012.24.017
体外心脏震波对急性心肌梗死模型猪左心室重塑的影响
Effect of extracorporeal cardiac shock wave therapy on left ventricular remodeling in a porcine model of acute myocardial infarction
摘要
Abstract
BACKGROUND: Initial studies have confirmed that extracorporeal cardiac shock wave therapy can ameliorate metabolism of ischemia myocardium from the level of gene and cells. However, will the therapy improve the development of post-infarction ventricular remodeling in a morphology level?OBJECTIVE: To explore the effects of extracorporeal cardiac shockwave therapy on the function and morphology of the left ventricle after acute myocardial infarction.METHODS: A total of 25 pigs were randomly divided into three groups: shock wave group, sham shock wave group and sham operation group. Pigs in the shock wave group were treated with extracorporeal cardiac shock wave therapy on 3, 5 and 7 days after the model construction of myocardial infarction. Pigs in the sham shock wave group received the same therapy to the shock wave group except for the shock waves and energy. Sham operation group received the same treatment to the sham shock wave group without constructing the myocardial infarction model.RESULTS AND CONCLUSION: Compared with the sham shockwave group, shockwave therapy significantly reduced the left ventricular end-systolic volume, increased the end-diastolic volume and improved the global left ventricular function (P< 0.001); it significantly improved the ventricular wall motor function in the myocardium of the myocardial infarction border zone and the motion compatibleness of the left ventricular. These findings demonstrate that the early application of effective extracorporeal cardiac shock wave therapy can delay the development to some extent from reversible stage to irreversible stage in the left ventricular remodeling after myocardial infarction.关键词
心脏震波/心室重塑/猪/心肌梗死/心功能分类
医药卫生引用本文复制引用
陶四明,郭涛,王钰,李建美,蔡红雁,羊超..体外心脏震波对急性心肌梗死模型猪左心室重塑的影响[J].中国组织工程研究,2012,16(24):4453-4458,6.基金项目
云南省社会攻关项目(2006SG10)和云南省社会发展计划项目(2008CD007). （2006SG10）
