中国组织工程研究2012，Vol.16Issue(24)：4467-4470,4.DOI:10.3969/j.issn.1673-8225.2012.24.020
实验性牙髓炎模型兔的构建
Construction of experimental pulpitis models in rabbits
摘要
Abstract
BACKGROUND: Animal models of pulpitis have been established using endotoxin in the past; however, they cannot fully reflect the formation process of clinical pulpitis.OBJECTIVE: To observe the inflammatory characteristics at different time points of rabbit models of pulpitis induced by Streptococcus mutans.METHODS: The mandibular anterior teeth of 20 healthy New Zealand rabbits were divided into experiment group and control group. The lingual surfaces of the rabbit mandibular anterior teeth were drilled; normal saline was imported into the control tooth, while Streptococcus mutans was imported into the experiment tooth. Five rabbits were sacrificed on 1, 3, 5 and 7 days after operation, respectively; inflammation outcomes of pulpitis was observed.RESULTS AND CONCLUSION: Inflammatory reaction in the experiment group was slight on 1 day after operation, and was aggravated gradually on 3, 5 and 7 days after operation, accompanied with vascular hyperemia in the pulp, severe effusion and necrosis of the pulp tissue. Inflammation in the control group was aggravated gradually as time went on; very few necrosis were found in the pulp tissues. These findings indicate that the forming process of pulpitis induced by Streptococcus mutans is more suitable to the pathological features of pulpitis.关键词
牙髓炎/动物模型/炎症/兔/组织学分类
医药卫生引用本文复制引用
毛小泉,邢璐,谈顺,吴多荣,徐普,黄茜..实验性牙髓炎模型兔的构建[J].中国组织工程研究,2012,16(24):4467-4470,4.基金项目
海南省自然科学基金资助项目(807091). （807091）
