中国组织工程研究2012，Vol.16Issue(24)：4530-4534,5.DOI:10.3969/j.issn.1673-8225.2012.24.033
核转录因子Nrf2最新研究进展
Latest research progress of nuclear transcription factor Nrf2
摘要
Abstract
BACKGROUND: Nuclear transcription factor Nrf2 belongs to the activated transcription factor family of leucine-zipper. It is related to antioxidant response, anti-inflammatory response and cytoprotection.OBJECTIVE: To summarize the function of nuclear transcription factor Nrf2 and its relationship with tumor prognosis, antineoplastic property and other diseases of the body system.METHODS: An online search of PubMed database was performed for articles published between January 1990 and July 2011 with the keyword of "Nrf2, Keap1" in English. Articles related to basic research and clinical practice of nuclear transcription factor Nrf2 was included. Obsolete or repetitive articles were excluded. A total of 50 articles were retained in the end.RESULTS AND CONCLUSION: Nrf2 is not only related to anti-oxidative stress, but to the occurrence, progression and metastasis of tumors. Meanwhile, it is found that Nrf2 is related to many diseases and intoxication in the body system other than oxidative stress-induced disease. Nrf2 inducers may become a potential drug for gene-targeted therapy.关键词
核转录因子/Nrf2/Keap1/氧化应激/细胞保护作用分类
医药卫生引用本文复制引用
李雪丽,唐云,许雪珠..核转录因子Nrf2最新研究进展[J].中国组织工程研究,2012,16(24):4530-4534,5.基金项目
国家教育部回国人员科研启动基金(第40批). （第40批）
