摘要
Abstract
Objective To investigate the effect of atorvastatin on the blood lipid and left ventricular function in essential hypertension patients. Methods Totally 118 essential hypertension patients with grade 1 or 2 were enrolled. These patients were randomly divided into two groups after 4 week blood pressure control with irbesartan. Patients in group A as control group ( n = 59 ) continued the same treatment, and patients in group B as experimental group ( n = 59 ) were treated with atorvastatin 20 mg/day based on the original treatment. This trial continued for 24 weeks. The levels of blood lipid and the variation of left ventricular function by ultrasonic cardiogram in the two groups were compared before and after 24 week treatment. Results There was no statistical significance to compare the levels of blood lipid in group A and group B pre treatment ( P > 0. 05 ); The changes of the levels of TC, LDL-C, HDL-C and TG were showed no statistical significance pre and post treatment in control group ( P > 0. 05 ), while the changes in group B had significance difference ( P < 0. 05 ); After the treatment, the levels of TC and LDL-C in group B were significantly lower than those of group A, thus there was statistical significance ( P < 0. 05 ), but there was no obvious changes in TG and HDL-C ( P > 0. 05 ). There was no significant changes in LVEF before and after the 24-week treatment in both groups ( P > 0. 05 ). The indexes of IVST,LVM, LVMI, and LA were reduced in group A after the treatment ( P <0. 05 ), but there was no obvious change in LVDd, LVSd, LVPWT and E/A ratio( P >0. 05 ); The IVST, LVPWT, LVM, LVMI were reduced and E/A ratio increased in group B after the treatment ( P < 0.05 ). Compard the two groups after treatment, there were significant differences except LVEF( P < 0. 05 ). Conclusion ( 1 )For patients with mild or moderate essential hypertension, treatment with irbesartan and atorvastatin could not only reduce the blood lipids level, but also alleviate the atrium and ventricle pressure, reverse the atrium and ventricle enlargement and ventricular hypertrophy, and could also improve left ventricular diastolic function significantly.( 2 )Atorvastatin may have no effects on left ventricular systolic function for patients with mild or mediator essential hypertension.关键词
阿托伐他汀/高血压,原发性/血脂/心功能Key words
Atorvastatin/ Hypertension,essential/ Blood lipids/ Cardiac function
