厄贝沙坦对自发性高血压慢性肾功能衰竭大鼠肾功能的影响及机制研究OACSTPCD
Effect of irbesartan on renal function in chronic renal failure of spontaneously hypertensive rats and its mechanism
目的 观察厄贝沙坦对自发性高血压大鼠慢性肾功能衰竭(SHR-CRF)模型肾功能的影响并探讨其机制.方法 SHR随机分为模型组及厄贝沙坦高、中、低剂量组,另设Wistar大鼠作为对照组.采用SHR进行5/6肾切除复制SHR-CRF模型.造模后予大鼠灌胃给药,连续8周.观察一般状况、血压,测定血液中尿素氮(BUN)、肌酐(Cr)浓度及尿液中尿蛋白(UP)、BUN、Cr、尿微量白蛋白(mALB)的浓度;采用荧光定量PCR测定肾转化生长因子-β1(TGF…查看全部>>
Objective To investigate the effect of irbesartan on renal function in chronic renal failure of spontaneously hypertensive rats ( SHR-CRF ) and its mechanism. Methods SHR were randomly divided into four groups: the model group, irbesartan high, middle, and low group. Wistar rat was used as control group. The model of SHR-CRF rats were established by 5/6 nephrectomize in SHR rats. All groups were irrigated for 8 weeks. The general condition was recorded. The …查看全部>>
孙琪;石宇杰;戚国庆;张健;张艳苓
100700,北京军区总医院心肺二区100700,北京军区总医院心肺二区050031,石家庄,河北医科大学第一医院心内科100700,北京军区总医院心肺二区100700,北京军区总医院心肺二区
厄贝沙坦自发性高血压肾功能衰竭,慢性TGF-β1/Smad3信号通路大鼠
Irbesartan Spontaneous hypertension Renal failure, chronic TGF-β1/Smad3 Rat
《疑难病杂志》 2012 (7)
531-534,4
吴阶平医学基金会临床科研专项资助(No.320.6700.1173)
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