应用化学2012，Vol.29Issue(4)：402-409,8.DOI:10.3724/SP.J.1095.2012.00251
4-氨基吡啶催化6-烷氧基取代嘌呤衍生物的合成
Synthesis of O6-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine
摘要
Abstract
A series of O6-substituted purine derivatives was designed and prepared through an efficient and convenient method with 4-amino-pyridine as the catalyst in methanol solvent. Under optimized conditions; n(6-chloropurine) :n(4-amino-pyridine) :n( triethylamine) =10:1 = 4, refluxing for 5 ～7 h, the yield of 6-alkoxy purine was greater than 85%. Studies showed that, the relative amount of 6-chloropurine, 4-aminopyridine and triethylamine in the system had a great influence on the reaction, and the highest catalytic activity was achieved using a mixture of 4-amino-pyridine and triethylamine as the catalyst.关键词
氨基吡啶/嘌呤/催化/烷氧基化/合成Key words
amino-pyridines/purine/catalyst/oxyalkylation/synthesis分类
化学化工引用本文复制引用
陆鸿飞,武鼎铭,孙垒垒,高玉华..4-氨基吡啶催化6-烷氧基取代嘌呤衍生物的合成[J].应用化学,2012,29(4):402-409,8.基金项目
江苏省自然科学基金(BK2009721)、江苏科技大学青年骨干教师支持计划(37060902)资助项目 （BK2009721）
