针刺研究2012，Vol.37Issue(1)：46-52,7.
电针正常人足三里和关元穴中枢效应的fMRI脑功能成像比较
Comparison of Brain Effects of Electroacupuncture at Zusanli (ST 36) and Guanyuan (CV 4)Shown by fMRI in 21 Healthy Volunteers
摘要
Abstract
Objective To observe different brain effects of electroacupuncture (EA) stimulation of Guanyuan (CV 4) and Zusanli (ST 36) in the normal subjects by using functional magnetic resonance image (fMRI). Methods Twenty-one healthy volunteers were recruited in the present study- fMRI was used to investigate brain responses [blood-oxygenation-level-dependent (BOLD) signals] to EA stimulation of CV 4 and ST 36. A filiform silver needle was inserted into CV 4 or the left ST 36 randomly in two consecutive fMRI tests, and then manipulated with uniform reducing-reinforcing methods to induce "Deqi". fMRI scan was performed before needling, during needle retention, during EA stimulation, and post-EA. Volunteer's subjective needling sensations were recorded after EA. Data of fMRI were analyzed by using software SPM 2 and fMRI was mapped by Degree Centrality Measure method for whole brain correlation. The activation, deactivation, short-distance and long-distance functional connectivity maps of cerebral regions were investigated. Results The fullness and numbness feelings of the subjects were stronger during EA at ST 36 than at CV 4. EA at ST 36 or CV 4 induced apparent similar deactivation effects in the anterior cingulate and medial prefron-tal cortices. The default mode of the brain at rest state was modified by needle retention and EA stimulation, respectively. The functional brain network was significantly changed after EA. The instant post-acupuncture effects (enhancement of the shortdis-tance functional connectivity) were mainly found in the ventral medial prefrontal cortex (VMPF) and ventral anterior cingulate cortex (vACC) in the limbic-paralimbic-neocortical network, and there were a little bit stronger signals in ST 36 than in CV 4. ConclusionEA stimulation of CV 4 and ST 36 induces a similar modulation effect in the limbic-medial prefrontal network in healthy subjects.关键词
电针/fMRI/脑功能连接/穴位特异性/关元穴/足三里穴Key words
Electroacupunctures/fMRI/Brain functional connectivity/Acupoint specificity/ZusanlKST 36)/ Guanyuan (CV 4)分类
医药卫生引用本文复制引用
方继良,宋明,刘保延,朱兵,王小玲,王寅,洪洋,刘河生,刘军,王雷,薛超,周科华..电针正常人足三里和关元穴中枢效应的fMRI脑功能成像比较[J].针刺研究,2012,37(1):46-52,7.基金项目
美国国立卫生研究院替代医学中心(NIH/NCCAM:1F05AT003022-01-04)、2008国家自然科学基金面上课题(30870668)、2006广安门医院基金课题(504) （NIH/NCCAM:1F05AT003022-01-04）
