中国动脉硬化杂志2012，Vol.20Issue(3)：221-225,5.
血管内皮生长因子在动脉粥样硬化缺血性脑卒中模型大鼠脑组织中的表达
The Regulation of Vascular Endothelial Growth Factor Expression after Cerebral Ischemia Stroke in Atherosclerotic Rats Model
摘要
Abstract
Aim To investigate the regulation of vascular endothelial growth factor (VECF) expression after cer-ebral ischemia stroke in atherosclerotic rats model. Methods Rats were randomly divided into control group and mod-el group, and then the latter, established into the atherosclerotic rats model, were randomly divided into five groups; ather-osclerosis (As)-sham, As rat model with sustained ischemia (As-SI) 0. 5, 6, 12, 24 h. The cerebral tissues were ana-lyzed with the level of VEGF mRNA by reverse transcription polymerase chain reaction ( RT-PCR) and the level of VEGF protein by immunohistochemical method. Results To compare each type of rat model groups with control, and com-pare four-time-points rat model groups with As-sham, the formers were significantly up-regulated ( P < 0.05 ) , and changed regularly with the four-time points,among which VEGF mRNA and its protein productions had reached the peak in As-SI 6 h group. Conclusions The present study showed that atherosclerotic disease had some positive effects on the expres-sion of VEGF gene and its outcomes during cerebral ischemia stoke happened, and changed with the four-time points. Meanwhile, it had provided a theory to evaluate the occurrence, development, treatment and prognosis of cerebral ischemia stroke complicated by atherosclerotic disease.关键词
缺血性脑卒中/动脉粥样硬化/血管内皮生长因子Key words
Cerebral Ischemia Stroke/ Atherosclerosis/ Vascular Endothelial Growth Factor分类
医药卫生引用本文复制引用
皇甫斌,段虎斌,刘跃亭,夏添,贾志亮..血管内皮生长因子在动脉粥样硬化缺血性脑卒中模型大鼠脑组织中的表达[J].中国动脉硬化杂志,2012,20(3):221-225,5.基金项目
山西省自然基金青年科技研究基金项目(20100210344) （20100210344）
