中国动脉硬化杂志2012，Vol.20Issue(3)：265-272,8.
新疆汉族和哈萨克族人群内皮型一氧化氮合酶基因T786C和G894T多态性与原发性高血压的相关分析
Association of G894T, T786C Polymorphisms of eNOS Gene with Essential Hypertension in the Han and Kazakh Populations in Xinjiang
摘要
Abstract
Aim To investigate the association of the G894T,T786C polymorphism of the endothelial nitric syn-thase (eNOS) gene with essential hypertension (EH) in the Han and Kazakh populations in Xinjiang. Methods Based on the case-control study ,346 patients with essential hypertension( EH group) and 385 healthy people ( NT group) in Han Chinese population, and 363 patients with essential hypertension (EH group) and 370 healthy people ( NT group) in the Kazakh population were selected from Tacheng Region of China by random cluster sample. After physical examination and questionnaire, blood samples were selected, the G894T,T786C polymorphisms of eNOS gene were detected with SNaPshot system. Genotype frequency, allele frequency, linkage disequilibrium (LD)and haplotypes were calculated and compar-ed.Results Overweight, obesity, triglycerides disorder, age 51 and over are risk factors of EH in Han and Kazakhpopulations. Distribution of allele frequencies G894T, T786C polymorphism of eNOS gene, the total population in EH and NT group are significantly different between two ethnic (P< 0.05). G894T and T786C polymorphism do not have strong LD. It constituted four kinds of haplotypes of GT (75. 3% and 79. 6% ) , GC (10. 8% and 10. 5% ) , TT (5. 7% and 9. 8%),TC (8.2% and 0. 1% ) in Han and Kazakh populations. The maximum distribution of haplotypes frequencies was GT in two ethnic, and the minimum are TC (Han) , TT ( Kazakh). The formation of haplotypes ( GT, TT, TC ) frequency was significantly different between two ethnic (P< 0.05). Conclusions The polymorphism of eNOS gene G894T, T786C may not be associated with the essential hypertension in the Han and Kazakh populations in Xinjiang.关键词
内皮型一氧化氮合酶/原发性高血压/新疆汉族/哈萨克族/基因多态性Key words
Endothelial Nitric Oxide Synthase/ Essential Hypertension/ Han Population in Xinjiang/ Ka-zakh/ Gene Polymorphism分类
医药卫生引用本文复制引用
张强,邓峰美,何芳,王树人,卢贤贵,王刚,邹放君,钟华,唐斌..新疆汉族和哈萨克族人群内皮型一氧化氮合酶基因T786C和G894T多态性与原发性高血压的相关分析[J].中国动脉硬化杂志,2012,20(3):265-272,8.基金项目
国家自然科学基金(30860102和30860079)资助 （30860102和30860079）
