中国康复理论与实践2012，Vol.18Issue(5)：426-429,4.DOI:10.3969/j.issn.1006-9771.2012.05.009
脑源性神经营养因子在孤独症模型鼠颞叶皮层中的表达
Expression of Brain-derived Neurotrophic Factor in Temporal Cortex of Autism Model Rats
摘要
Abstract
Objective To explore the role of brain-derived neurotrophic factor (BDNF) in pathogenesis of autism. Methods 12.5 d pregnant Wistar rats were injected sodium valproate (VPA) 600 mg/kg or normal saline (NS). Their newborn rats were observed ethologically. The expression of BDNF was measured in their temporal cortex with immunohistochemical stain. Results Compared with NS group, VPA group expressed less body mass (P<0.05), eyes opening delay (P<0.05), poorer coordination response (P<0.05), slower taxis response (P< 0.05). The number of social behavior decreased (P<0.05), latency increased (P<0.05), duration shortened (P<0.05), repetitive activities increased (P<0.05). Purkinje cells reduced in cerebellum. The expression of BDNF increased significantly in temporal cortex 1 d, 7 d and 14 d postnatally (P<0.01), but decreased 35 d and 49 dpostnatally (P<0.01). Conclusion BDNF plays a role in the pathogenesis of autism.关键词
孤独症/脑源性神经营养因子/丙戊酸钠/大鼠Key words
autism/ brain-derived neurotrophic factor/ sodium valproate/ rats分类
医药卫生引用本文复制引用
陈淑娟,姜志梅,郭岚敏,张士岭,孙奇峰,李丽,王长山..脑源性神经营养因子在孤独症模型鼠颞叶皮层中的表达[J].中国康复理论与实践,2012,18(5):426-429,4.基金项目
佳木斯大学研究生创新科研项目(YJSCX2011-018JD). （YJSCX2011-018JD）
