中国康复理论与实践2012，Vol.18Issue(5)：444-447,4.DOI:10.3969/j.issn.1006-9771.2012.05.014
预防性抗生素应用对重症脑卒中急性期感染和预后的影响
Effects of Antibiotic Prophylaxis on Infection and Prognosis after Severe Stroke
王强 1马剡芳 1左鹰 1李建国 1刘易新 1张龙友 1于东明1
作者信息
- 1. 首都医科大学附属北京天坛医院急诊科,北京市,100050
- 折叠
摘要
Abstract
Objective To investigate the effects of antibiotic prophylaxis on the incidence of infection and prognosis in acute phase after severe stroke. Methods 165 patients within 24 h from clinic onset were divided into the intervention group and control group. The intervention included cefuroxime+metronidazole or moxifloxacin. The body temperature was continuously monitored, and the presence of infection was daily assessed with C-reactive protein (CRP), leukocyte count, and bedridden X-ray. They were also assessed with Glasgow Coma Scale (GCS) and Acute Pathologic and Chronic Health Evaluation (APACHE)- II. Primary end points was incidence of infection; secondary end points included death and other clinical outcome. Results There was no difference between tow groups in infection rate (P=0.58), interval until diagnosis of infection (P=0.74), so as mortality (P=1.00) and interval of death (P=0.84), body temperature (P=0.99), CRP (P= 0.37) , leukocyte (P=0.51), scores of GCS (P=0.31) and APACHE- II (P=0.28). Conclusion Antibiotic prophylaxis works little to prevent infection and improve outcome in patients with acute stroke.关键词
脑卒中/感染/预防性抗生素Key words
stroke/ infection/ antibiotic prophylaxis分类
医药卫生引用本文复制引用
王强,马剡芳,左鹰,李建国,刘易新,张龙友,于东明..预防性抗生素应用对重症脑卒中急性期感染和预后的影响[J].中国康复理论与实践,2012,18(5):444-447,4.
