中国临床药理学与治疗学2012，Vol.17Issue(2)：137-140,4.
鼠神经生长因子诱导骨髓间充质干细胞向神经元样细胞分化的实验研究
Differentiation of rat bone marrow stromal cells into neurol cells induced by mouse nervous growth factor
摘要
Abstract
AIM: To observe the effect of mouse nervous growth factor(mNGF) on differentiation of rat bone marrow stromal cells into neurol cells. METHODS: 60 4-week-old healthy clean SD rats were equally randomized into divided into treatment group (n = 30) and normal control group(n = 30). The treatment group received 0.1 μg/mL mNGF as induction medium. The rats BMSCs of passage 3 were cultured in the medium with or without previous brain tissue extracts. The expressions of neuron specificencolase (NSE) were detected after 3 days by immunocytochemistry. RESULTS: There were a few NSE in the normal control group. The expression of NSE of treatment group were significantly higher than normal control group ( P < 0.01). CONCLUSION- mNGF can induce BMSCs into neural cells.关键词
鼠神经生长因子/骨髓间充质干细胞/细胞分化Key words
Mouse nervous growth factor/ Bone marrow stromal cells/ Cell differentiation分类
医药卫生引用本文复制引用
陈再丰,许信龙,魏晓捷,傅小君,潘红松,谢青松..鼠神经生长因子诱导骨髓间充质干细胞向神经元样细胞分化的实验研究[J].中国临床药理学与治疗学,2012,17(2):137-140,4.基金项目
慈溪市科技局资助项目(CN2010021) （CN2010021）
