中国临床药理学与治疗学2012，Vol.17Issue(2)：175-180,6.
鸢尾黄素对肝星状细胞外基质表达的影响
Effects of tectorigenin on the secretion of extracellular matrix in Hepatic stellate cells
王志勇 1吴俊华 2王玉蓉 2余德才 1丁义涛1
作者信息
- 1. 南京大学医学院附属鼓楼医院肝胆研究所,南京210008,江苏
- 2. 南京大学医学院,南京210008,江苏
- 折叠
摘要
Abstract
AIM: To investigate the effect of tectorigenin on the secretion of extracellular ma-genin at different concentrations, the mRNA expression of a-SMA, pro-collagen-a1 ( I ), MMP-13 and TIMP-1 were detected by real-time PCR. RESULTS: Tectorigenin significantly decreased the expression of a-SMA in HSC-T6. As well as the mRNA expression of pro-collagen-ai , and tectorigenin significantly elevated the mRNA expression of MMP-13, while decreasing the mRNA expression of TIMP-1. CONCLUSION: Tectorigenin could reduce the synthesis and secre-trix (ECM) in Hepatic stellate cells. METHODS- HSC-T6 cells were incubated with tectori-tion of type I collagen in HSC, thereby reducing the deposition of extracellular matrix; the other hand, tectorigenin could promote the degradation of extracellular matrix, so as to have anti-fibrosis potentials.关键词
鸢尾黄素/肝纤维化/肝星状细胞/胞外基质Key words
Tectorigenin/ Liver fibrosis/ Hepatic stellate cells/ Extracellular matrix分类
医药卫生引用本文复制引用
王志勇,吴俊华,王玉蓉,余德才,丁义涛..鸢尾黄素对肝星状细胞外基质表达的影响[J].中国临床药理学与治疗学,2012,17(2):175-180,6.
