中国临床药理学杂志2012，Vol.28Issue(3)：175-178,4.
不同剂量阿折地平在中国健康人体内的药代动力学
Pharmacokinetics of different dosages of azelnidipine in healthy volunteers
于丽秀 1黄露 1葛苗苗 1黎维勇1
作者信息
- 1. 华中科技大学同济医学院附属协和医院临床药学室,武汉430022
- 折叠
摘要
Abstract
Objective To study the phamacokinetics of different dosages of azelnidipine in Chinese healthy volunteers. Methods Twenty-four healthy volunteers were devided into three groups. The volunteers in the three groups received single dose of 16 mg azelnidipine, single dose of 8 mg azelnidipine and multiple dosing of 8 mg azelnidipine by oral adminis-tration (8 mg per day,7 days continuous) .respectively. Concentrations of azelnidipine in plasma were determined by HPLC/MS/MS. The pharma-cokinetics parameters were calculated by SPSS 13. 0 software. Results The main pharmacokinetic parameters of the three groups were as follows: Cmax were (10.61 ±3. 93),(5.91 ±2.83) and (5.88 ±1.90) μg· L-1; Tmax were (3. 67 ±0. 99), (3. 33 ± 1. 30) and (3. 17 ±0.72) h; t1/2 were (28.00 ±7.72), (20.34 ±7.60) and (28. 17 ±7.93)h; AUC0-t were ( 139. 50 ± 72. 90 ) , ( 61. 17 ± 33. 78 ) and ( 86. 72 ± 41. 59) μg·h·L-1. respectively. The steady -state AUC,, for multiple was(55. 54 ± 18. 78) μg·h·L-1. The main pharmacokinetics parameters had no significant difference in AUC0-t/D, AUC0-∞,/D, Cmax/D ex-cept tl/2. The half - time of multiple dosing was longer than that of single dose and there was a decline in the values of CLz/F, which had statistical difference ( P < 0. 05 ).Conclusion Pharmacokinetic characteristics of azelnidipine in Chinese healthy volunteers showed a linear relationship, within the dose range of 8 - 16 mg; Azelni-dipine with administration of a single oral dose daily had almost no accumulation effect in Chinese.关键词
阿折地平/药代动力学/液相串联质谱法Key words
azelnidipine/pharmacokinetics/HPLC/MS/MS分类
医药卫生引用本文复制引用
于丽秀,黄露,葛苗苗,黎维勇..不同剂量阿折地平在中国健康人体内的药代动力学[J].中国临床药理学杂志,2012,28(3):175-178,4.
