中国临床药理学杂志2012，Vol.28Issue(3)：218-220,3.
严重药物不良反应相关药物标记基因多态性研究状况
Advances in search for genetic polymorphism of pharmacogenetic biomarkers about severe adverse drug reactions
古先祥 1王启华2
作者信息
- 1. 张掖医学高等专科学校医学遗传学教研室,甘肃 张掖 734000
- 2. 临沂市皮肤病医院 皮肤科,山东 临沂 276003
- 折叠
摘要
Abstract
Severe adverse drug reactions , which appear to be idiosyncrat-ic and unpredictable, are a major issue for drug therapy . Genetic factors or genome polymorphisms contribute to the susceptibility or heterogenei-ty. More discovery of risk alleles for these severe drug reactions may ben-efit the prediction of individuals. In this review, we clarify the current status of the genetic polymorphism of pharmacogenetic biomarkers about severe adverse drug reactions in skin and liver from open data sources.关键词
基因多态性/药物不良反应/史蒂文斯-约翰孙综合症/中毒性表皮坏死松解症/药物性肝损害Key words
genetic polymorphism/ adverse drug reactions/ Stevens -Johnson syndrome/ toxic epidermal necrolysis/ drug - induced liver injury分类
医药卫生引用本文复制引用
古先祥,王启华..严重药物不良反应相关药物标记基因多态性研究状况[J].中国临床药理学杂志,2012,28(3):218-220,3.
