中国临床药理学杂志2012，Vol.28Issue(5)：333-337,5.
多药耐药基因MDR1C1236T多态性与炎症性肠病患者的活性代谢物6-TGNs的相关性
Relationship between MDR1C1236T polymorphism and active metabolite of 6-thioguanine nucleotide in patients with the inflammatory bowel disease
摘要
Abstract
Objective To investigate the relationship between multidrug resistance gene (MDR1) C1236T and 6 - thioguanine nucleotide concentrations (6 -TGNs) and thiopurine - induced adverse effects in patients with inflammatory bowel disease (IBD). Methods Blood samples and clinical data were collected from a cohort of 105 unrelated Chinese IBD patients who were receiving azathioprine ( AZA)/6 - mereaptopurine (6 -MP) therapy. MDR1C1236T genotype was detected by polymerase chain reaction and restriction fragment length polymorphism ( PCR -RFLP) , and erythrocyte 6 - TGNs were determined by HPLC. The associations between MDR1 C1236T genotype and 6 - TGNs level/adverse effects were evaluated using chi - square test Results 6 - TGNs concentration was found higher in 1236 TT/CT carriers than that in 1236CC carriers treated with the same dose of AZA/6 - MP(P =0. 048). Meanwhile, a positive correlation between 1236CT/TT and adverse effects was found in IBD patients ( P - 0. 045 ). Conclusion MDR1 1236 C > T mutants play important role in higher 6 - TGNs concentration and higher incidence of adverse reactions.关键词
多药耐药蛋白/基因多态性/炎症性肠病/6-硫鸟苷酸Key words
multidrug resistance protein/ gene polymorphism/ inflammatory bowel disease/ 6 - thioguanine nucleotide分类
医药卫生引用本文复制引用
冯静,陈瑜君,王雪丁,黄民,高翔,胡品津,李嘉丽,陈旻湖,陈白莉,何瑶,张羽,龙顺华..多药耐药基因MDR1C1236T多态性与炎症性肠病患者的活性代谢物6-TGNs的相关性[J].中国临床药理学杂志,2012,28(5):333-337,5.基金项目
国家自然科学基金资助项目(81072708 （）
81173131 （）
81102515) （）
