中国临床药理学杂志2012，Vol.28Issue(5)：340-342,345,4.
艾司西酞普兰与西酞普兰治疗抑郁症的对照研究
Escitalopram vs citalopram: a parallel controlled study for depression
颜景祥 1王健 1杜波 1赵素银 1崔利军 1孙秀丽1
作者信息
- 1. 河北省第六人民医院,河北保定071000
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of escitalo-pram in treatment of depression. Methods A randomized, double -blind, active drug controlled clinical trial was conducted. One hundred twenty - six patients met with CCMD - 3 criteria of depression received 6 weeks treatment with escitalopram (1-2 weeks with oral 10 mg, 3 -6 weeks with flexible dosages 10 - 20 mg, n =63) or citalopram (1-2 weeks with oral 20mg, 3-6 weeks with flexible dosages 20 -40 mg, re =63). The primary clinical efficacy was evaluated with the change in total score of 17 - items Hamilton Depression Rating Scale ( HAMD -17) ,HAMA, GCI, and the safety with the reports of adverse events, the result of laboratory or electrocardiography examination, etc. Results Total of 106 patients completed the study, 52 in escitalopram group and 54 in citalopram group, with total response rates (82.1% vs 88. 9% , P = 0.484)and remission rates(36. 5% vs 27. 8% ,P = 0. 36). There were no significant differences between the two groups (P > 0.05) in total response rates, remission rates and the score of the HAMA, GCI at all time points. The incidence of adverse events and drug - related adverse event were well tolerated, with no significant difference in the prevalence between the two groups (17.5% vs 30. 2% ,P =0.07). Conclusion Escitalopram has similar therapeutic effect to citalopram, and rapid onset, better tolerability.关键词
艾司西酞普兰/西酞普兰/抑郁症Key words
escitalopram/ citalopram/ depression分类
医药卫生引用本文复制引用
颜景祥,王健,杜波,赵素银,崔利军,孙秀丽..艾司西酞普兰与西酞普兰治疗抑郁症的对照研究[J].中国临床药理学杂志,2012,28(5):340-342,345,4.
