中国临床药理学杂志2012，Vol.28Issue(5)：367-369,3.
侧脑室注射士的宁对七氟烷致小鼠遗忘作用的影响
Effects of strychnine injection intracerebroventricular on the amnestic mice induced by sevoflurane
摘要
Abstract
Objective To investigate the relationship between strychnine - sensitive glyeine receptor and the amnesia induced by sevoflurance in mice. Methods Amnestic model was established by intraperitoneal injection of sevoflurane before intracerebroventricular injection of different doses of strychnine (0.05, 0. 10, 0. 15 u.g) or artificial cerebrospinal fluid, then step down latency (SDL), error times in step down test and step through latency ( STL) and error times in step through test were observed and recorded. Results Compared with the NS group, strychnine had no significant effect on SDL, STL and error times of mice. Sevoflurane significantly reduced SDL and STL of mice and increased error times (P < 0. 05 ) . Intracerebroventricular injection of strychnine increased SDL and STL and decreased error times significantly of the mice treated with sevoflurane in both step down test and step through test (P < 0.05). Conclusion The current study provides the evidence that is strychnine - sensitive glyeine receptor involved in sevoflurance induced amnesia.关键词
士的宁/甘氨酸受体/七氟烷/遗忘Key words
strychnine/ glyeine receptor/ sevoflurance/ amnesia分类
医药卫生引用本文复制引用
张云倩,汪燕,倪云成,金培培,马黎娜,戴体俊,许鹏程..侧脑室注射士的宁对七氟烷致小鼠遗忘作用的影响[J].中国临床药理学杂志,2012,28(5):367-369,3.基金项目
国家自然科学基金资助项目(39970715) （39970715）
江苏省自然科学基金资助项目(BK2001143) （BK2001143）
