中国临床药理学杂志2012，Vol.28Issue(5)：385-387,3.
雷美替胺治疗慢性失眠疗效的荟萃分析
Meta-analysis of remalteon on the treatment of chronic insomnia
徐国友 1王丹1
作者信息
- 1. 台州第一人民医院药剂科,浙江 台州318020
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of remalteon in chronic insomnia based on Meta - analysis. Methods Studies using randomized , double - blind, placebo - controlled, parallel or crossover designs with remalteon in adults with chronic insomnia that were published between 1966 and 2011 in English were selected for review. The weighted mean difference (WMD) of self - report and polysomnographic measures of sleep - onset latency, total sleep time between remalteon and placebo were calculated. Results Total 7 studies including 3186 cases were analyzed. Ramelteon significantly reduced self - report ( WMD = - 5. 37 min, P < 0. 00001) and polysomnographic (WMD = - 10.12 rain, P < 0. 00001) sleep - onset latency, and increased self - report ( WMD = 4. 22 min, P = 0. 04) and polysomnographic ( WMD = 6. 22 min, P = 0. 03) total sleep time compared to placebo. Conclusion The above-mentioned results support the effectiveness of remalteon for the treatment of chronic insomnia.关键词
慢性失眠/雷美替胺/荟萃分析Key words
chronic insomnia/ remalteon/ Meta - analysis分类
医药卫生引用本文复制引用
徐国友,王丹..雷美替胺治疗慢性失眠疗效的荟萃分析[J].中国临床药理学杂志,2012,28(5):385-387,3.
