中国临床医学2012，Vol.19Issue(2)：91-93,3.
记忆提取对小鼠树突棘的形态学影响
Effect of Memory Recall on the Morphology of Dendritic Spines in Mice
摘要
Abstract
Objective:To investigate the effect of memory recall on the morphology of dendritic spines in green fluorescent pro-tcin(GFP) transgenic mice. Methods: Twelve male GFP transgenic mice received spacial navigation training in Morris water maze until they met the memory formation criteria. Then the mice were randomly allocated to cither the place recall test group (re = 6) or the control group(? = 6). Morphology of dendritic spines was observed through laser confocal microscopy. Densities of dendritic spines were compared between the two groups. Results: The density of dendritic spines in the test group was 1. 69 (1. 47 - 2. 00)spincs/jLim(18 cells,65 dendritic segments,3 034 spines) and the density of dendritic spines in the control group was 1.33 (1. 04 ~ 1. 55)spincs/jLim(18 cells,66 dendritic segments, 2 723 spines). The density of dentritic spines in the test group was greater than that in the control group (P<0. 05). Conclusions: Memory recall process can increase the density of dendritic spines in pyramidal cells in the hippocampus Cal region of mice, which indicates that memory recall process may be accompanied by formation of new excitatory synapses.关键词
Morris水迷宫/树突棘/记忆回想Key words
Morris water maze/ Dendritic spines/ Mental recall分类
医药卫生引用本文复制引用
张晓光,薛张纲..记忆提取对小鼠树突棘的形态学影响[J].中国临床医学,2012,19(2):91-93,3.基金项目
国家自然科学基金资助(编号:81100796) （编号:81100796）
