中国临床药学杂志2012，Vol.21Issue(2)：99-102,4.
西妥昔单抗联合化疗方案治疗晚期结直肠癌的临床疗效
Clinical investigation of cetuximab treatment combined with radio- and chemotherapy in advanced colorectal cancer patients
周陈西 1刘孟娟 1王增 1朱利明2
作者信息
- 1. 浙江省肿瘤医院,药剂科,杭州310022
- 2. 浙江省肿瘤医院,化疗科,杭州310022
- 折叠
摘要
Abstract
AIM To investigate the response and adverse drug reactions of cetuximab treatment combined with radio- and chemo- therapy in advanced colorectal cancer patients. METHODS From Jan. 2007 to Jun. 2010, clinical data of 35 patients with advanced or metastatic colorectal cancer treated by cetuximab singly or by cetuximab combined with chemotherapy were analyzed.The clinical curative effect and adverse drug reactions as well as the effective response rate of patients with wild-type K-RAS were studied. RESULTS There .was one patient reached complete response (CR), 9 patients reached partial response(PR), 14 patients were in stable condition (SC), and the 7 patients were disease progression (DP). The effective response rate was 32.3%, disease control rate(DCR) was 75.0%. The effective response rate(40.0%)of patients with wild-type K-RAS was better than untested group(18.2%). The adverse effect incidencerate was 94.3%, and I - II grade adverse drug reactions happened most 6equently which accounted for 74.1%. CONCLUSION The effective response rate of cetuximab treatment combined with radio- and chemo- therapy in advanced colorectal cancer patients is pretty high, and the combination treatment which prolonged the time-to-progression (TIP) and is worthy of clinical application.关键词
靶向治疗/西妥昔单抗/药物不良反应Key words
targeted therapy/ cetuximab/ adverse drug reaction引用本文复制引用
周陈西,刘孟娟,王增,朱利明..西妥昔单抗联合化疗方案治疗晚期结直肠癌的临床疗效[J].中国临床药学杂志,2012,21(2):99-102,4.
