中国普通外科杂志2012，Vol.21Issue(3)：253-256,4.
微创置管引流对重症急性胰腺炎早期炎症反应的影响
Minimally invasive catheter drainage lessens the early inflammatory response of severe acute pancreatitis
摘要
Abstract
Objective: To investigate the therapeutic effect of minimally invasive catheter drainage on early inflammatory response of severe acute pancreatitis (SAP).Methods: Fifty-seven SAP patients with peritoneal effusion were divided into the observation group (29 cases with minimally invasive catheter drainage) and control group (28 cases with conventional drainage) using a random number table. Both groups underwent the same basic regimen of treatment, and then the observation group received the minimally invasive drainage while the control group had conventional ultrasound-guided catheter drainage. The inflammatory indexes responding to acute inflammatory such as TNF-α, IL-6, IL-8 and CRP were detected before and after treatment. Meanwhile, the recovery time of bowel function, and duration of systemic inflammatory response syndrome (SIRS) and incidence of multiple organ dysfunction syndrome (MODS) were observed.Results: The acute inflammatory response occurred in the both groups, and all the serum inflammatory indexes detected in the both groups tended to gradually decrease with different degrees. The levels of TNF-α, IL-6 and CRP on day 3 and 7, and the level of IL-8 on day 7 after drainage in the observation group were significantly lower than those of the control group (all P<0.05). The recovery time of bowel function and the SIRS duration of the observation group were shorter than those of the control group (both P<0.05). Furthermore, the incidence of MODS of the observation group (13.8%) was also significantly lower than that of the control group (28.6%) (P<0.0l).Conclusion: Minimally invasive catheter drainage for SAP can lessen the early inflammatory response, accelerate bowel function recovery, and reduce the incidence of MODS.关键词
胰腺炎,急性坏死性/微创置管引流/全身炎症反应综合征/多器官功能不全综合征Key words
Pancreatitis, Acute Necrotizing/ Minimally Invasive Catheter Drainage/ Systemic Inflammatory Response Syndrome/ Multiply Organ Dysfunction Syndrome分类
医药卫生引用本文复制引用
张春霞,王敏,龙官保,张俊,郑建伟,申铭..微创置管引流对重症急性胰腺炎早期炎症反应的影响[J].中国普通外科杂志,2012,21(3):253-256,4.基金项目
国家自然科学基金面上资助项目(81172064) （81172064）
国家自然科学基金青年科学基金资助项目(81101621). （81101621）
