摘要
Abstract
Objective To investigate the efficacy of salicylazosulfapyridine combined with herbal coloclysis in the treatment of ulcerative colitis and its effect on serum interleukin - 2 ( IL - 2 ) and C - reactive protein ( CRP ). Methods The clinical data of 118 patients with ulcerative colitis admitted to our hospital from January 2008 to December 2010 were retrospectively analyzed. They were randomly divided into two groups: control group ( n = 58 ), in which patients were given oral salicylazosulfapyridine treatment ( 6. 0 g, tid; reduced to 4. 5 g, tid, after 15 days ); and treatment group ( n =60 ), in which patients were given herbal coloclysis qd in addition to the oral salicylazosulfapyridine treatment. Treatment in each group lasted both 20 days. The changes of IL - 2 and CRP levels were compared before and after treatment. Results The efficay was significantly superior in the treatment group than in the control group ( u = -3. 464, P <0. 01 ). In both groups, the IL - 2 levels were increased significantly after treatment, and the CRP levels were decreased significantly after treatment ( P < 0. 05 ). The IL - 2 and CRP levels of the treatment group were significantly better than those of the control group ( P < 0. 05 ). Conclusion The salicylazosulfapyridine combined with herbal coloclysis shows good efficacy in treating ulcerative colitis, which may be achieved by influencing the change of serum IL - 2 and CRP.关键词
柳氮磺胺吡啶/灌肠/结肠炎,溃疡性/C反应蛋白质Key words
Sulfasalazine/Enema/Colitis,ulcerative/C - reactive protein分类
医药卫生
